Research Opportunities

Matt Krantz, MD, MS
Assistant Professor of Medicine
Vanderbilt University Medical Center

Funding:

Supported by the:

• NIH/NIAID (K08 AI185260)

• AAAAI Foundation Faculty Development Award

Mentored by:

Elizabeth Phillips, MD
Director, Center for Drug Safety and Immunology

The Central Question

Why don’t all carriers of human leukocyte antigen (HLA) associated risk alleles develop drug hypersensitivity and allergic diseases?

The Approach

Can electronic health record (EHR)-linked biobanks be used to uncover the incomplete penetrance of HLA risk alleles for drug hypersensitivity and allergic diseases?

Disease Focus

HLA-A*32:01 associated vancomycin drug reaction with eosinophilia and systemic symptoms (DRESS)

DRESS symptoms

DRESS lab changes

What is an EHR linked biobank?

Skills that you can learn

Immunogenomics

Immunogenomic interactions

HLA

HLA Class I

Killer-cell immunogloblulin like receptors (KIR)

Endoplasmic reticulum aminopeptidases

T-cell receptors

Phenotyping in electronic health records

Data structure in EHR

Bioinformatic data analysis

Computing in the cloud

Short read whole genome sequencing

Long read whole genome sequencing

Biobanks we have access to

Questions and Thank you!