Drug Reaction with Eosinophilia and Systemic Symptoms

Work in Progress Updated Feb 6, 2026

Signs and symptoms of DRESS

Nikolsky negative blistering on dependent surfaces due to significant underlying edema. Purpura is also found on dependent surfaces (lower extremities).

Lymphadenopathy (cervical, axillary, epitrochlear, inguinal).

Polymorphic rashes associated DRESS

Typical timing of select laboratory changes seen in DRESS

Latency by drug for DRESS

RegiSCAR criteria

https://doi.org/10.1111/bjd.12501

DRESS Review Paper in NEJM (Blumenthal)

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