All of Us

Background

Started in Precision Medicine Initiative 2015 during State of Union Address Jan 30, 2015

https://obamawhitehouse.archives.gov/node/333101

Originall called the Precision Medicine Initiative Cohort Program

Workbench

Workbench

Data Browser

Data Browser

https://www.researchallofus.org/

All x All Browser

https://allbyall.researchallofus.org

X01 Biospecimens All of Us

https://www.joinallofus.org/article/nih-all-of-us-research-program-invites-researchers-to-apply-for-first-ever-biospecimen-access

Genomic DNA samples: 370,000+ participants Serum samples: 329,000+ participants Plasma samples: 343,000+ participants

HLA

path vwb-aou-datasets-controlled/v9/wgs/short_read/snpindel/hla_variants

Information about costs and billing accounts

https://support.researchallofus.org/hc/en-us/articles/360039539411-Getting-Started-and-What-to-Know-About-Costs

Setting Up Billing Account

https://support.researchallofus.org/hc/en-us/articles/29349213795348-Setting-Up-Your-Google-Cloud-Platform-GCP-Billing-Account

Example Projects

Khajouei, Ehsan, Valentina Ghisays, Ignazio S. Piras, Kiana L. Martinez, Anthony T. Vicenti, Marcus Naymik, Preston Ngo et al. “Phenome-wide association of APOE alleles in the All of Us Research Program.” EBioMedicine 117 (2025)